How Long Has Semaglutide Been Around? A History of This Weight Loss & Diabetes Drug

The History of Semaglutide

1. Early Development & Discovery

• Semaglutide is a GLP-1 receptor agonist, inspired by naturally occurring hormones that regulate appetite and blood sugar.
• Novo Nordisk developed semaglutide as a longer-lasting alternative to earlier GLP-1 medications, such as liraglutide.

2. FDA Approvals & Medical Use

• 2017: The FDA approved Ozempic (weekly injectable) for type 2 diabetes management.
• 2019: Rybelsus (oral semaglutide) was introduced, offering a daily tablet form.
• 2021: Wegovy became the first semaglutide formulation approved specifically for weight loss.

3. Expansion & Global Use

• Semaglutide is now widely used in over 50 countries for diabetes and weight management.
• Research continues on higher doses and long-term effects, with potential applications in metabolic disease prevention.

Key Takeaways

• Semaglutide was first developed for diabetes before being approved for weight loss.
• Ozempic, Wegovy, and Rybelsus are the most well-known semaglutide medications.
• Ongoing research explores new formulations and long-term safety.

Sources

1. Novo Nordisk, “The Development of Semaglutide” https://www.novonordiskf.com/products/semaglutide.html
2. The New England Journal of Medicine, “Semaglutide in Diabetes and Obesity Treatment” https://www.nejm.org/doi/full/10.1056/NEJMoa2032183
3. Singapore Ministry of Health, “GLP-1 Medications for Metabolic Health” https://www.moh.gov.sg/newsroom/glp-1-receptor-agonist-drugs-approved-for-treatment-of-diabetes-and-obesity