Semaglutide & Nausea: Why It Happens & How to Manage It

Why Does Semaglutide Cause Nausea?

1. Delayed Gastric Emptying

• Semaglutide slows digestion, making you feel full longer but also leading to bloating and nausea.
• High-fat or large meals can worsen symptoms due to slower stomach emptying.

2. Dosage Adjustments & Sensitivity

• Nausea is more common during dose increases, as the body adjusts to the medication.
• Some individuals experience persistent nausea, requiring slower dosage progression.

How to Reduce Nausea While Taking Semaglutide

1. Adjust Your Eating Habits

• Eat smaller, more frequent meals instead of large portions.
• Avoid greasy, high-fat, and spicy foods, which can trigger nausea.

2. Stay Hydrated

• Drink small sips of water or herbal teas throughout the day.
• Avoid carbonated beverages and excessive caffeine, which can worsen symptoms.

3. Take Semaglutide at the Right Time

• Some people find taking it before bed helps minimize daytime nausea.
• Avoid lying down immediately after eating.

4. Consider Over-the-Counter Remedies

• Ginger tea or peppermint can help soothe nausea naturally.
• Your doctor may recommend anti-nausea medications if symptoms persist.

Key Takeaways

• Nausea is a common side effect of semaglutide, especially during dose increases.
• Eating smaller meals, staying hydrated, and adjusting timing can help reduce discomfort.
• Most patients find that nausea improves as their body adjusts over time.

Sources

1. The New England Journal of Medicine, “Gastrointestinal Effects of GLP-1 Medications” https://www.nejm.org/doi/pdf/10.1056/NEJMoa1901118
2. Singapore Ministry of Health, “Managing Side Effects of Weight Loss Medications” https://www.moh.gov.sg
3. American Diabetes Association, “Semaglutide and Digestion: Clinical Insights” https://diabetesjournals.org/care/article/48/3/e25/157716/One-Size-Does-Not-Fit-All-Understanding